Ketonal (ketoprofen) 30g cream
Sandoz
Condition: Brand New
EXP: 11/2025
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Indications
Ketonal
Symptomatic therapy aimed at reducing pain and inflammation in the following conditions:
osteoarthritis of various localizations;
periarthritis, tendinitis, bursitis, myalgia, neuralgia, radiculitis;
injuries of the musculoskeletal system (including sports), bruises of muscles and ligaments, sprains, ruptures of ligaments and muscle tendons.
The penetration of topical NSAIDs through the skin depends on the physical and chemical properties of the cream components. The rate of release and absorption of ketoprofen in the form of a cream for topical use depends on the excipient of the drug. Compared to the oral form, the relative bioavailability of ketoprofen in the form of a cream is about 5%. Ketoprofen in cream form mainly acts locally and does not have a systemic effect.
Distribution
Ketoprofen is predominantly bound to plasma proteins (99%). Penetrates into joint tissues, incl. into the synovial fluid, and reaches therapeutic concentrations there. At the same time, the concentration of ketoprofen in the blood plasma remains insignificant. When applied topically in the form of a cream, Cmax of ketoprofen in plasma is observed after 6 hours. Significant concentrations are present in subcutaneous fat, periarticular tissues and synovial fluid. The effect of the drug in tissues lasts up to 12 hours.
Metabolism and excretion
Ketoprofen is metabolized in the liver to form conjugates, which are excreted primarily by the kidneys. The metabolism of ketoprofen does not depend on age, the presence of severe renal failure or liver cirrhosis. Ketoprofen is gradually eliminated by the kidneys.
Ketoprofen is one of the most effective cyclooxygenase inhibitors. It also inhibits the activity of lipoxygenase and bradykinin. Stabilizes lysosomal membranes and prevents the release of enzymes involved in the inflammatory process.
The main properties of ketoprofen are pronounced analgesic, anti-inflammatory and antipyretic effects. When using local forms of ketoprofen for damaged ligaments, back pain or joint pain, the analgesic effect of the drug appears 30 minutes after application.
Ketoprofen does not have a negative effect on the condition of articular cartilage.
Dosing
For external use.
A small amount of cream (3-5 cm) with light rubbing movements is applied in a thin layer to the skin of the inflamed or painful area of the body in accordance with its area 2 times a day. The duration of treatment without consulting a doctor should not exceed 14 days.
If necessary, Ketonal cream can be combined with other dosage forms of Ketonal (capsules, tablets, rectal suppositories, solution for IV and IM administration).
The maximum dose of ketoprofen is 200 mg/day.
Occlusive dressing is not recommended.
If the patient forgets to apply the cream, it should be used at the time the next dose is due, but not double it.
Contraindications:
hypersensitivity to ketoprofen or other components of the drug;
hypersensitivity to salicylates, tiaprofenic acid or other NSAIDs, fenofibrate, UV blockers, fragrances;
indications in the anamnesis of attacks of bronchial asthma or allergic rhinitis caused by taking NSAIDs and salicylates;
III trimester of pregnancy;
children under 15 years of age;
violation of the integrity of the skin in the area where the cream is applied (eczema, acne, weeping dermatitis, open or infected wound);
history of photosensitivity reactions;
exposure to sunlight, incl. indirect sunlight and UV irradiation in a solarium throughout the entire treatment period and for another 2 weeks after stopping treatment with the drug.
With caution: impaired liver and/or kidney function, erosive and ulcerative lesions of the gastrointestinal tract, blood diseases, bronchial asthma, chronic heart failure.
Use in children
Use is contraindicated in children under 15 years of age.
Storage conditions
should be stored out of the reach of children at a temperature not exceeding 25°C.
available without a prescription.
